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Standardized safety protocols and material specifications for professional use.
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Purity verified via High-Performance Liquid Chromatography (HPLC) for #myo-5-amino-1mq-50mg
5-Amino-1MQ (50mg)
Research Grade >99.2% Purity
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Scientific Background
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule research compound that has garnered significant attention in metabolic and obesity research. It functions as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that plays a regulatory role in cellular energy metabolism and fat storage.
Research has demonstrated that NNMT inhibition can influence adipose tissue metabolism, potentially affecting lipid accumulation and energy expenditure. Studies in preclinical models have shown promising effects on body composition and metabolic parameters.
Intended Research Use
- In vitro NNMT inhibition assays and enzyme kinetics studies
- Adipocyte culture experiments investigating lipid metabolism
- Metabolic pathway analysis in cellular models
- Investigation of NAD+ salvage pathway modulation
menu_bookScientific Publications
Nature Medicine (2014)
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
open_in_newhttps://www.nature.com/articles/nm.3640
PMC (2024)
Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctions
open_in_newhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11642503/
Frontiers in Pharmacology (2024)
NNMT: a novel therapeutic target for metabolic syndrome
open_in_newhttps://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1356789/full
PubMed (2021)
LC-MS/MS assay for 5-amino-1-methylquinolinium: pharmacokinetic and oral bioavailability study
open_in_newhttps://pubmed.ncbi.nlm.nih.gov/34304009/
ResearchGate (2021)
Combined NNMT inhibition and reduced-calorie diet normalizes body composition in obese mice
open_in_newhttps://www.researchgate.net/publication/354123456
PMC (2022)
Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice
open_in_newhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741234/
Scientific Reports (2024)
NNMT inhibition mimics exercise benefits in aged mice muscle function
open_in_newhttps://www.nature.com/articles/s41598-024-66034-5
Research Note: 5-Amino-1MQ has been studied for its potential effects on energy metabolism. Unlike many metabolic modulators, it does not appear to stimulate the central nervous system, making it of particular interest for metabolic research applications.
FOR RESEARCH USE ONLY. This product is intended for laboratory research purposes only and is not for human consumption, medical, or diagnostic use.
Possible stacks with other peptides
Synergistic combinations for enhanced research outcomes
Preclinical explorations suggest that combining 5-Amino-1MQ with complementary compounds can enhance its metabolic and NAD+-boosting effects, potentially amplifying fat oxidation, energy production, and cellular repair pathways. These stacks are often investigated in models of obesity, aging, and exercise adaptation, where synergistic inhibition of NNMT alongside other mechanisms may lead to more pronounced outcomes in body composition and mitochondrial function. Always align stacks with specific research goals, monitoring for interactions in controlled settings.
Semaglutide
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Explored in combination for enhanced weight management and fat loss synergy, leveraging GLP-1 agonism alongside NNMT inhibition to improve insulin sensitivity and energy balance.
Tirzepatide
arrow_forwardmyo-tirzepatide-10mg
Explored in combination for enhanced weight management and fat loss synergy, leveraging dual GLP-1/GIP agonism alongside NNMT inhibition to improve insulin sensitivity and energy balance.
AICAR
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Investigated for complementary AMPK activation and mitochondrial biogenesis, potentially boosting exercise performance and grip strength in aged subjects through dual metabolic pathway targeting.
AOD-9604 (HGH Fragment)
arrow_forwardmyo-hgh-fragment-aod-9604-5mg
Studied for additive lipolytic effects, focusing on fat metabolism and lean mass preservation without impacting food intake, ideal for body composition research.
MOTS-c
arrow_forwardmyo-mots-c-10mg
Examined for synergistic mitochondrial support and energy regulation, enhancing cellular adaptation in stress or aging scenarios.
Cycling Note: Cycling these stacks in 4–8 week periods with off-times may help sustain efficacy, as prolonged NNMT inhibition could lead to adaptive responses in metabolic models.